Cancer registry system is an important tool that is used to understand cancer burden in a particular setting, and inform relevant authorities on the current trend in order to establish an appropriate cancer control plan. In Nigeria, cancer is becoming a serious challenge due to a poor observance of occurrences. Cancer remains one of the leading chronic diseases and among one of the main cause of morbidity and mortality in the Nigeria: 100,000 new incidences of cancer occur every year with a momentous proportion of 15%, contribute to 681,000 new estimated cancer cases occurred in Africa 2008. This shows the increase in cancer incidence in the country.  This study was aimed to identify, assess, and itemize all the available standards and requirements related to cancer registry, and design and develop appropriate cancer registry systems that will ensure quality cancer data are recorded and maintain. Online systematic search was conducted between the periods of 4th July, 2017 to 12th September, 2017 on PubMed, ProQuest and Web of Science databases to identify literatures that described any beneficial standards for cancer registries or reporting system and registry requirements, guidelines, protocols or policies. Conceptual model was created and common data elements are identified based on analyzing included literatures, and content validity ratio (CVR) and content validity index (CVI) was calculated based on experts view regarding the model. Thirty seven articles met the inclusion criteria for the standards and twenty five publications for requirements were included in this study. In total, 19 standards have been observed alongside with various requirements, and were categorized and presented. Registry was designed and developed using open source (CanReg) software system. Huge disparity among countries in Africa, Asia, and Central and South American regions was observed, where policy on cancer registration is yet to be matured. Our review discovered that this disparity is as a result of lack of multi-partner overseeing organization that coordinates and ensure uniform standards for maintaining registry activities. Without observing standards at registry level, National Control Program cannot access quality data from the registry for cancer control plan. We recommend multidisciplinary committee on cancer be instituted and a quality control program should be established that will review and checkmate the registration procedure and develop reward for best registry.